Version: XP, Vista, 7
If your internal drive is incorrectly listed as one of the options under the Safely Remove Hardware icon, it's a glitch that only affects certain motherboards, including many with Nvidia chipsets.
Thankfully, you can remove your internal drive's entry with a simple Registry tweak. Open the Registry Editor, browse to HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Services\nvata, and then select Edit > New > DWORD value.
Type "DisableRemovable" into the New Value #1 box, then press [Enter] and double-click "DisableRemovable". Change its value to 1, restart your computer and the glitch will be gone.